| splendidly | brillamment |
| Splendidness | Majesté |
| splendiferous | magnifique |
| splendor | splendeur |
| splenectomy | splénectomie |
| splenetic | splénétique |
| Spliceosome | Spliceosome |
| splicer | colleuse |
| spline | cerce |
| splint | attelle |
| splinter | éclat |
| splinter group | formation |
| splinter off | se scinder |
| split | rupture |
| Split Airport | Aéroport de Split |
| Split album | Split |
| split end | fourche |
| split ends | pointes fendues |
| split open | se rompre |
| split pea | pois cassé |
| split personality | double personnalité |
| split ring | anneau brisé |
| split up | se séparer |
| Split-complex number | Nombre complexe fendu |
| split-level | à sols dénivelés |
| split-second | fraction de seconde |
| splits | grand écart |
| splitting | abominable |
| Splitting circle method | Méthode du cercle de séparation |
| Splitting field | Corps de décomposition |
| Splitting maul | Merlin |
| splitting up | séparation |
| splurge | engloutir |
| splutter | grésiller |
| spluttery | postillonneux |
| Splügen | Splügen |
| Splügen Pass | Col du Splügen |
| SPO | SPO |
| Spock | Spock |
| spoil | tourner |
| spoil with | contaminer |
| spoilage | décomposition |
| spoiled brat | enfant gâté |
| spoiled child | enfant gâté |
| spoiler | becquet |
| spoils | butin |
| spoils of war | butin de guerre |
| spoilsport | rabat-joie |
| spoilt | pourri |
| spoilt for choice | avoir |
| Spoilt vote | Vote nul |
| Spokane | Spokane |
| spoke | rayon |
| Spoke-hub distribution paradigm | Hub and spoke |
| spoken | parlé |
| spoken for | pris |
| spoken language | langue parlée |
| Spoken languages of Canada | Langues du Canada |
| spokesman | porte-parole |
| spokesperson | porte-parole |
| spokeswoman | porte-parole |
| Spoleto | Spolète |
| spoliate | piller |
| spoliation | pillage |
| spondaic | spondaïque |
| Sponde | Spondé |
| spondee | spondée |
| Spondias mombin | Prunier mombin |
| Spondias purpurea | Spondias purpurea |
| Spondylus | Spondylus |
| sponge | quémander |
| sponge cake | gâteau de Savoie |
| sponge down | nettoyer à l'éponge |
| sponge off | vivre en parasite |
| sponge on | vivre en parasite |
| sponger | parasite |
| Spongin | Spongine |
| Spongocoel | Spongocoele |
| spongy | spongieux |
| sponsor | sponsor |
| spontaneity | spontanéité |
| spontaneous | impulsif |
| spontaneous combustion | combustion vive |
| Spontaneous fission | Fission spontanée |
| spontaneous generation | génération spontanée |
| Spontaneous human combustion | Combustion spontanée |
| Spontaneous ignition | Combustion spontanée |
| spontaneous reaction | réaction instinctive |
| Spontaneous symmetry breaking | Brisure spontanée de symétrie |
| spontaneously | spontanément |
| spontaneousness | spontanéité |
