| Sphingidae | Sphingidae |
| sphinx | esfinge |
| sphygmomanometer | esfigmomanómetro |
| Sphynx | Sphynx |
| Sphyrnidae | Sphyrnidae |
| spic-and-span | impecable |
| spice | entusiasmo |
| Spice Girls | Spice Girls |
| Spice trade | Descubrimiento de la ruta marítima a la India |
| spicebush | benjoin |
| Spices | Especia |
| spick-and-span | impecable |
| Spicules | Espícula |
| spicy | aromático |
| Spiddal | An Spidéal |
| spider | araña |
| Spider bite | Características del veneno de araña |
| spider monkey | mono araña |
| spider wasp | pompílido |
| spider web | telaraña |
| spider's web | tela de araña |
| Spider-Man | Spiderman |
| Spider-Man film series | Spiderman |
| Spider-Woman | Spider-Woman |
| spiders | hilar |
| spiderweb | telaraña |
| spidery | delgado |
| Spiez | Spiez |
| Spiff and Hercules | Pif y Hércules |
| spiffy | pulcro |
| spigot | grifo |
| spike | pincho |
| spike heel | tacón de aguja |
| Spike Lee | Spike Lee |
| spikes | zapatillas con clavos |
| spiky | erizado |
| spill | aliviadero |
| spill out | desahogarse |
| spillage | derrame |
| spillway | aliviadero |
| spin | girar |
| spin doctor | asesor de imagen |
| Spin glass | Vidrio de espín |
| spin out | alargar |
| Spin round | Abombarse |
| spin-drier | secador centrífugo |
| spin-dryer | secador centrífugo |
| spin-off | derivado |
| spina bifida | espina bífida |
| spinach | espinaca |
| Spinacia | Spinacia oleracea |
| spinal | espinal |
| spinal column | espina dorsal |
| spinal cord | médula espinal |
| Spinal cord injury | Lesión de la médula espinal |
| Spinal disc herniation | Hernia de disco |
| spindle | eje |
| Spindle apparatus | Huso mitótico |
| Spindle override | Interferencia |
| spindly | larguirucho |
| spindrift | rocío del mar |
| spine | espina |
| spine board | tablero |
| spine-chilling | atemorizante |
| Spined loach | Capra |
| spinel | espinela |
| spineless | invertebrado |
| spinet | espineta |
| Spinlock | Spinlock |
| spinnaker | spinnaker |
| spinner | cebo de cuchara |
| spinning | hilado |
| spinning jenny | hiladora |
| Spinning roller coaster | Montaña rusa giratoria |
| spinning top | trompo |
| spinning wheel | rueca |
| Spinone Italiano | Spinone |
| spinor | espinor |
| Spinosauridae | Spinosauridae |
| Spinosauroidea | Spinosauroidea |
| Spinosaurus | Spinosaurus |
| spinster | soltera |
| Spintronics | Espintrónica |
| Spinx | Esfinge |
| spiny | espinoso |
| spiny dogfish | mielga |
| spiny lobster | langosta |
| Spiny mouse | Acomys |
| Spiny rat | Echimyidae |
| SPIP | SPIP |
| Spiraeoideae | Spiraeoideae |
| spiral | dar vueltas |
| Spiral arm | Galaxia espiral |
| Spiral galaxy | Galaxia espiral |
| Spiral model | Espiral de Boehm |
| Spiral of silence | Espiral del silencio |
| spiral staircase | escalera de caracol |
| spiraled | enrollado |
| spiralled | enrollado |
| Spiranthes | Spiranthes |
| spire | aguja |
| Spiridon Louis | Spiridon Louis |
| Spiringen | Spiringen |
| spirit | alcohol |
| spirit level | nivel |
| spirit of the age | espíritu de la época |
| spirit of the times | espíritu de la época |
| Spirit rover | Spirit |
| spirited | arrojado |
| Spirited Away | El viaje de Chihiro |
| spiritism | espiritualismo |
| spiritist | espiritista |
| Spiritist doctrine | Doctrina Espírita |
| spiritistic | espiritista |
| spiritless | apático |
